Biography

Dr. Carol Lau obtained her Bachelor of Science and Doctor of Philosophy in the University of Hong Kong. She worked in the Department of Orthopedics and Traumatology, and School of Biomedical Sciences, respectively in the Chinese University of Hong Kong before joining Hong Kong Metropolitan University. Dr. Lau has research interests on Plant Reproductive Biology, Tumorigenesis and Pathology of Bone Tumors, and Raman Spectroscopy.

Teaching Areas & Research Interests

• Plant Reproductive Biology
• Tumorigenesis and Pathology of Bone Tumors
• Raman Spectroscopy

Selected Publications

Journal Articles

• Carol PY Lau*, Wenao Ma, Kwan Yau Law, Maribel Lacambra, Kwok Chuen Wong, Chien Wei Lee, Oscar Lee, Qi Dou, Shekhar Madhukar Kumta. Development of Deep Learning Algorithms to Discriminate Giant Cell Tumor of Bone from Adjacent Normal Tissues by Confocal Raman Spectroscopy. Analyst, 2022,147, 1425-1439
• Carol P. Y. Lau*, Cathy S. H. Fung, Kwok Chuen Wong, Yu-Hsuan Wang, Lin Huang, Stephen K. W. Tsui, Oscar K. Lee, Shekhar M. Kumta. Simvastatin Possesses Antitumor and Differentiation‐Promoting Properties That Affect Stromal Cells in Giant Cell Tumor of Bone. Journal of Orthopaedic Research 2020-02-11 | journal-article DOI: 10.1002/jor.24456
• Xi Zeng, Joseph Chi-Ching Tsui, Mai Shi, Jie Peng, Cyanne Ye Cao, Lea Ling-Yu Kan, Carol Po-Ying Lau, Yonghao Liang , Lingyi Wang , Li Liu, Zhiwei Chen, Stephen Kwok-Wing Tsui. Genome-Wide Characterization of Host Transcriptional and Epigenetic Alterations During HIV Infection of T Lymphocytes. Front Immunol. 2020 Sep 10;11:2131. DOI: 10.3389/fimmu.2020.02131. eCollection 2020.
• Xiao-Yu Liu, Kevin Yi Yang, Ming-Qiang Wang, Jamie Sui-Lam Kwok, Xi Zeng, Zhiyuan Yang, Xiao-Jun Xiao, Carol Po-Ying Lau, Ying Li, Zhi-Ming Huang, Jin-Ge Ba, Aldrin Kay-Yuen Yim, Chun-Yan Ouyang, Sai-Ming Ngai, Ting-Fung Chan, Elaine Lai-Han Leung, Liang Liu, Zhi-Gang Liu, Stephen Kwok-Wing Tsui. High-quality assembly of Dermatophagoides pteronyssinus genome and transcriptome reveals a wide range of novel allergens. Journal of Allergy and Clinical Immunology 2018 | journal-article DOI: 10.1016/j.jaci.2017.11.038
• Patrick Kwok Shing Ng, Carol Po Ying Lau*, Emily Kai Yee Lam, Sheila Sai Kam Li, Vivian Wai Yan Lui, Winnie Yeo, Yuen Keng Ng, Paul Bo San Lai & Stephen Kwok Wing Tsui. Hypermethylation of NF-kappa B-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis. Digestive Diseases and Sciences 2018 | journal-article DOI: 10.1007/s10620-018-4929-3
• Carol P.Y. Lau*, Jamie S.L. Kwok, Joseph C.C. Tsui, Lin Huang, Kevin Y. Yang, Stephen K.W. Tsui, Shekhar Madhukar Kumta. Genome-Wide Transcriptome Profiling of the Neoplastic Giant Cell Tumor of Bone Stromal Cells by RNA Sequencing. Journal of Cellular Biochemistry 2017 | journal-article DOI: 10.1002/jcb.25792
• Shihui Chen, Carol Po ying Lau, Ming Lei, Jiang Peng, Tao Tang, Xiaohong Wang, Ling Qin, Shekhar-Madhukar Kumta. Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model. Journal of Tissue Engineering and Regenerative Medicine 2017 | journal-article DOI: 10.1002/term.1828
• Shekhar Kumta, Carol PY Lau, KC Wong. Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice. Journal of Bone and Soft Tissue Tumors Sep-Dec 2017;3(2): 6-9
• Joseph Chi-Ching Tsui, Carol Po-Ying Lau*, Alex Chun Cheung, Kwok-Chuen Wong, Lin Huang, Stephen Kwok-Wing Tsui, Shekhar Madhukar Kumta. Differential expression of filamin B splice variants in giant cell tumor cells. Oncology Reports 2016 | journal-article DOI: 10.3892/or.2016.5197
• Carol P. Y. Lau*, Kwok Chuen Wong, Lin Huang, Gang Li, Stephen K.W. Tsui, Shekhar Madhukar Kumta. A mouse model of luciferase-transfected stromal cells of giant cell tumor of bone. Connective Tissue Research 2015 | journal-article DOI: 10.3109/03008207.2015.1075519
• Carol P. Y. Lau*, Lin Huang, Kwok Chuen Wong, Shekhar Madhukar Kumta. Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone. Connective Tissue Research 2013 | journal-article DOI: 10.3109/03008207.2013.848202
• Wayne Y.W. Lee, Ting Zhang, Carol P.Y. Lau, C.C. Wang, Kai-Ming Chan, Gang Li. Immortalized human fetal bone marrow-derived mesenchymal stromal cell expressing suicide gene for anti-tumor therapy in vitro and in vivo. Cytotherapy 2013 | journal-article DOI: 10.1016/j.jcyt.2013.06.010
• Carol Po Ying Lau*, Patrick Kwok Shing Ng, Man Shan Li, Stephen Kwok Wing Tsui, Lin Huang, Shekhar Madhukar Kumta. p63 regulates cell proliferation and cell cycle progression-associated genes in stromal cells of giant cell tumor of the bone. International Journal of Oncology 2013 | journal-article DOI: 10.3892/ijo.2012.1727
• T Tang, G Zhang, Carol PY Lau, L Z Zheng, X H Xie, X L Wang, X H Wang, K He, Y Patrick, L Qin. Effect of water-soluble P-chitosan and S-chitosan on human primary osteoblasts and giant cell tumor of bone stromal cells. Biomedical Materials 2011 | journal-article DOI: 10.1088/1748-6041/6/1/015004
• Carol P.Y. Lau*, Lin Huang, Stephen K.W. Tsui, Patrick K.S. Ng, Pui-Yin. Leung, Shekhar M. Kumta. Pamidronate, Farnesyl Transferase, and Geranylgeranyl Transferase-I Inhibitors Affects Cell Proliferation, Apoptosis, and OPG/RANKL mRNA Expression in Stromal Cells of Giant Cell Tumor of Bone. Journal of Orthopaedic Research 2011 | journal-article DOI: 10.1002/jor.21249
• Patrick Kwok-Shing Ng, Stephen Kwok-Wing Tsui, Carol Po-Ying Lau, Chi-Hang Wong, Winnie Hiu-Ting Wong, Lin Huang, Shekhar-Madhukar Kumta. CCAAT/Enhancer Binding Protein Beta Is Up-Regulated in Giant Cell Tumor of Bone and Regulates RANKL Expression. Journal of Cellular Biochemistry 2010 | journal-article DOI: 10.1002/jcb.22556
• Carol P. Y. Lau*, Richard M. K. Saunders, Lawrence Ramsden. Floral biology, breeding systems and population genetic structure of three climbing Bauhinia species (Leguminosae: Caesalpinioideae) in Hong Kong, China. Journal of Tropical Ecology 2009 | journal-article DOI: 10.1017/S0266467408005762
• Carol P. Y. Lau*, Lawrence Ramsden, Richard M. K. Saunders. Hybrid origin of "Bauhinia blakeana" (Leguminosae : Caesalpinioideae), inferred using morphological reproductive, and molecular data. American Journal of Botany 2005 | journal-article DOI: 10.3732/ajb.92.3.525