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    Advances in Chemical Synthesis
    CHEM S445
      More information: Course Guide
    Advances in Chemical Synthesis

    Course Coordinator: Dr Kevin Cheuk

    Course Developer: Dr. Lo Chui Man, OUHK

    This course covers a wide range of advanced information in organic chemistry, including reaction mechanisms, and strategies for synthetic methods and their applications to the synthesis of natural products or other aspects. This advanced course expands on introductory chemical topics, including electrophilic addition, nucleophilic substitution and elimination reactions. In order to introduce students to modern synthetic strategies, this course will cover some selected journal articles and review papers that have received a great deal of attention in the current scientific world.

    Advisory prerequisite(s)
    You are advised to have already studied CHEM S345 so that you will have an advantage in understanding the basic principles and concepts of synthetic organic chemistry.

    This course aims to introduce students to advanced topics in organic chemistry, starting from reaction mechanisms and strategies of synthetic methods, and then continuing to their applications in the synthesis of natural products and other aspects. The course also encourages students to think critically about the synthetic routes to some selected natural products as reported in journal articles and review papers. Moreover, the course can develop students' ability to apply theoretical strategies related to synthetic tools to real examples of organic synthesis, and also motivate students to propose reasonable synthetic schemes and mechanisms for various organic reactions, as well as inspire students to appreciate the art of advanced organic chemistry.

    Topics to be covered in the course:

    • Reactivities and mechanisms: Chemical kinetics, reaction mechanisms, and resonance stabilizations

    • Carbon-carbon bond formation: C-C, C=C bond formations, organometallic coupling and pericyclic reactions

    • Reactive species and rearrangement: Reactions, migrations and rearrangements of carbocations, carbanions and free radicals

    • Asymmetric organocatalysis: Including some asymmetric organic reactions with high enantioselectivities or diastereoselectivities using metal-free organocatalysts

    • A case study covering total synthesis: From planning to application, to total synthesis of prostaglandins and taxol.

    Learning support
    There will be regular tutorials and surgeries with your tutors throughout the course.

    Laboratory classes
    Regular laboratory sessions will be arranged during the course, in which tutors and supervisors will guide you through the experiments related to the course content.

    There are three assignments designed to assess your progress in the course. All assignments will be counted toward the overall continuous assignment score. There will also be a three-hour final course examination at the end of the course. Students are required to submit assignments via the Online Learning Environment (OLE).

    Online support
    This course is supported by the Online Learning Environment (OLE). You can find the latest course information from the OLE. Through the OLE, you can communicate electronically with your tutor and the Course Coordinator as well as other students. To access the OLE, students will need to have access to the Internet. However, the use of the OLE is NOT compulsory for the study of this course.

    Students will need access to a personal computer or other electronic devices with an Internet connection.

    Set book(s)
    Narain, R P (2008) Mechanisms in Advanced Organic Chemistry, New Delhi: New Age International (P) Limited, Publishers. (The OUHK has access to the electronic version)

    Students with disabilities or special educational needs
    If you have impaired vision or hearing, the computer and audio work necessary for this course may present some difficulties. You are encouraged to seek further advice from the Course Coordinator if you feel that it will be physically challenging.

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